Vascular phenotype of amyloid precursor protein-deficient mice
نویسندگان
چکیده
منابع مشابه
Increased extracellular amyloid deposition and neurodegeneration in human amyloid precursor protein transgenic mice deficient in receptor-associated protein.
The low-density lipoprotein receptor-related protein (LRP) is an abundant neuronal cell surface receptor that regulates amyloid beta-protein (Abeta) trafficking into the cell. Specifically, LRP binds secreted Abeta complexes and mediates its degradation. Previously, we have shown in vitro that the uptake of Abeta mediated by LRP is protective and that blocking this receptor significantly enhanc...
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In several pedigrees of early onset familial Alzheimer's disease (FAD), point mutations in the beta-amyloid precursor protein (APP) gene are genetically linked to the disease. This finding implicates APP in the pathogenesis of Alzheimer's disease in these individuals. To understand the in vivo function of APP and its processing, we have generated an APP-null mutation in mice. Homozygous APP-def...
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Transgenic mice that express familial Alzheimer's disease mutant forms of the human amyloid precursor protein (hAPP) have proved to be invaluable in determining the impact that the neurotoxic amyloid-β peptide has in vivo. In addition to the propensity to accumulate cerebral amyloid plaques, a crucial characteristic of hAPP mouse models is their cognitive impairments. To date the most widely us...
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how to cite this article: bhadbhade a, cheng dw. amyloid precursor protein processing in alzheimer’s disease. iranian journal of child neurology2012;6(1):1-5. alzheimer’s disease (ad) is a progressive neurodegenerative disorder and a leading cause of dementia. the ad is characterized by presence of intraneuronal tangles and extracellular plaques in the brain. the plaques are composed of dense a...
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ژورنال
عنوان ژورنال: American Journal of Physiology-Heart and Circulatory Physiology
سال: 2019
ISSN: 0363-6135,1522-1539
DOI: 10.1152/ajpheart.00539.2018